Patterns of Expression and Analysis of Clusters of HIV/Host interactions
This resource allows the querying of cellullar responses to HIV infection.
The infected cell (SupT1 T cell) was subject of universal infection with a HIV-based vector (HIV-NL43Δenv/eGFP, VSV-g pseudotyped). Over 24h, the study recovered cellular transcriptome (mRNA, miRNA), viral life cycle intermediates (reverse transcription, integration, transcription, translation, and release), and integration site distribution.
The temporal patterns of the viral life cycle were used to explain the host genome-wide expression dynamics in response to the invading virus.